TCR–pMHC bond conformation controls TCR ligand discrimination

Constitutive and Ligand-Induced TCR

Altered Peptide Ligand-Mediated TCR

TCR down-regulation controls T cell homeostasis.

TCR and cytokine receptor signaling play key roles in the complex homeostatic mechanisms that maintain a relative stable number of T cells throughout life. Despite the homeostatic mechanisms, a slow decline in naive T cells is typically observed with age. The CD3gamma di-leucine-based motif controls TCR down-regulation and plays a central role in fine-tuning TCR expression and signaling in T ce...

Blumer internalization . activation , ligand discrimination , and receptor G - protein - coupled receptor controls pathway

Quantitative measurement of protease ligand conformation

The tendency for protease ligands to bind in an extended conformation has been suggested as an important factor for the identification of compounds of medicinal importance. Here we present a novel graph-theoretical method giving a quantitative measure of ligand conformation, and through application of this method to a representative set of protease ligands in bound and unbound conformations, de...